Hepatitis B virus capsid assembly Assembly pathway of hepatitis B core virus-like particles from genetically fused dimers
نویسندگان
چکیده
Background: We studied assembly of HBV capsids using a genetically-fused dimer. Results: Assembly intermediates composed of two, three and five copies of a fused dimer have been isolated. Conclusion: Capsid assembly could progress using dimeric, trimeric and pentameric intermediates. Significance: The low abundance and transient nature of assembly intermediates make analysis challenging, however, the stability of the intermediates described here has overcome this.
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تاریخ انتشار 2015